2143475-98-1
2143475-98-1
Chemical Structure
GeA-69
- CAS No.: 2143475-98-1
- Formula:C20H16N2O
- Molecular Weight:300.35
IUPAC Name: N-(2-(9H-carbazol-1-yl)phenyl)acetamide
InChIKey: LDPDVNYCIOHPGF-UHFFFAOYSA-N
SMILES: CC(NC1=CC=CC=C1C2=CC=CC3=C2NC4=C3C=CC=C4)=O
Biological Activity: GeA-69 is a selective, allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2 (MD2), with a Kd value of 2.1 μM. GeA-69 involves in DNA damage repair mechanisms and prevents recruitment of PARP14 MD2 to sites of laser-induced DNA damage[1][2].
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GeA-69 | 99.73% | GeA-69 is a selective, allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2 (MD2), with a Kd value of 2.1 μM. GeA-69 involves in DNA damage repair mechanisms and prevents recruitment of PARP14 MD2 to sites of laser-induced DNA damage. | ||||||||||||||||||||
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References
- [1]. Schuller M, et al. Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. ACS Chem Biol. 2017 Nov 17;12(11):2866-2874. [Content Brief]
- [2]. Moustakim M, et al. Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. Bioorg Med Chem. 2018 Jul 15;26(11):2965-2972. [Content Brief]
