2151032-62-9
Chemical Structure
Cendakimab
Synonym(s): RPC 4046; ABT 308; CC-93538
- CAS No.: 2151032-62-9
- Formula:N/A
- Molecular Weight:(146.44 kDa)
IUPAC Name: (E)-N-(4-((2-hydroxy-5-methylphenyl)diazenyl)phenyl)acetamide-2,2,2-d3
SMILES: [Cendakimab]
Biological Activity: Cendakimab (RPC4046; ABT 308; CC-93538) is a selective, humanized, recombinant monoclonal antibody against the IL-13 molecule. Cendakimab has a high affinity and potency for both human wild-type and variant IL-13 and blocks binding of IL-13 to both IL-13Rα1 and IL-13Rα2 with IC50s of 352 pM and 631 pM by ELISA, respectively. Cendakimab recognizes both wild-type human IL-13 and the common polymorphic variant R110Q, with binding affinities of 52 and 50 pM, respectively. Cendakimab has the potential for IL-13-related allergic/inflammatory diseases (e.g., asthma and eosinophilic esophagitis)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cendakimab | 99.96% | Cendakimab (RPC4046; ABT 308; CC-93538) is a selective, humanized, recombinant monoclonal antibody against the IL-13 molecule. Cendakimab has a high affinity and potency for both human wild-type and variant IL-13 and blocks binding of IL-13 to both IL-13Rα1 and IL-13Rα2 with IC50s of 352 pM and 631 pM by ELISA, respectively. Cendakimab recognizes both wild-type human IL-13 and the common polymorphic variant R110Q, with binding affinities of 52 and 50 pM, respectively. Cendakimab has the potential for IL-13-related allergic/inflammatory diseases (e.g., asthma and eosinophilic esophagitis). | ||||||||||||||||||||
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