2151063-66-8
Chemical Structure
DOTA-EB-TATE
- CAS No.: 2151063-66-8
- Formula:C105H133N21O30S5
- Molecular Weight:2329.63
InChIKey: ODSBLSVYNDTYQA-JKVIHPPVSA-N
SMILES: O=[S](O)(C(C(C=C1)=C2C(O)=C1/N=N/C(C=CC(C(C=C3)=CC(C)=C3NC([C@H](CCCCNC(CCN(C(C4)=O)C(C4SCCC(N[C@@H](C(N[C@@H](CSSC[C@H](NC([C@](NC5=O)([H])[C@H](O)C)=O)C(N[C@H](C(O)=O)[C@H](O)C)=O)C(N[C@H](C(N[C@@H](C(N[C@H]5CCCCN)=O)CC6=CNC7=CC=CC=C67)=O)CC8=CC=CC=C8)=O)=O)CC9=CC=CC=C9)=O)=O)=O)NC(CN(CCN(CC%10)CC(O)=O)CCN(CCN%10CC(O)=O)CC(O)=O)=O)=O)=C%11)=C%11C)=CC([S](=O)(O)=O)=C2N)=O
Biological Activity: DOTA-EB-TATE is composed of SST peptide derivative, DOTA-octreotate conjugated a common to an Evans blue analog (EB). DOTA-EB-TATE is a peptide drug conjugate (PDC) improves the pharmacokinetics of SSTR2 analogs and reduces PRRT toxicity. DOTA-EB-TATE can also be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DOTA-EB-TATE | 98.15% | DOTA-EB-TATE is composed of SST peptide derivative, DOTA-octreotate conjugated a common to an Evans blue analog (EB). DOTA-EB-TATE is a peptide drug conjugate (PDC) improves the pharmacokinetics of SSTR2 analogs and reduces PRRT toxicity. DOTA-EB-TATE can also be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). | ||||||||||||||||||||
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References
- [1]. Rui Tian, et al. Evans Blue Attachment Enhances Somatostatin Receptor Subtype-2 Imaging and Radiotherapy. Theranostics. 2018 Jan 1;8(3):735-745. [Content Brief]
- [2]. Vallabhajosula S. Design of Radiolabeled Peptide Radiopharmaceuticals[M]//Molecular Imaging and Targeted Therapy: Radiopharmaceuticals and Clinical Applications. Cham: Springer International Publishing, 2023: 577-607.
