2154327-48-5
Chemical Structure
C16G2
- CAS No.: 2154327-48-5
- Formula:C190H310N58O42
- Molecular Weight:4078.93
SMILES: O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(NCC(NCC(NCC(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC5=CNC=N5)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC6=CC=C(C=C6)O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N
Biological Activity: C16G2 is a specifically targeted antimicrobial peptide (STAMP) that targets the cariogenic oral pathogen (Streptococcus mutans). C16G2 links a CSP-derived targeting domain to the bactericidal domain G2 via glycine, thereby selectively binding to and disrupting the cell membrane of S. mutans, leading to the leakage of intracellular contents such as ATP and loss of membrane potential, ultimately causing cell death. C16G2 can be used for research on dental caries[1][2][3][4][5][6].
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C16G2 | C16G2 is a specifically targeted antimicrobial peptide (STAMP) that targets the cariogenic oral pathogen (Streptococcus mutans). C16G2 links a CSP-derived targeting domain to the bactericidal domain G2 via glycine, thereby selectively binding to and disrupting the cell membrane of S. mutans, leading to the leakage of intracellular contents such as ATP and loss of membrane potential, ultimately causing cell death. C16G2 can be used for research on dental caries. | |||||||||||||||||||||
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References
- [1]. Stacy A, et al. The biogeography of polymicrobial infection. Nature reviews. Microbiology. 2016 Feb;14(2):93-105.
- [2]. Li LN, et al. Targeted antimicrobial therapy against Streptococcus mutans establishes protective non-cariogenic oral biofilms and reduces subsequent infection. International journal of oral science. 2010 Jun;2(2):66-73.
- [3]. Batoni G, et al. Therapeutic Potential of Antimicrobial Peptides in Polymicrobial Biofilm-Associated Infections. International journal of molecular sciences. 2021 Jan 06;22(2):482.
- [4]. Kaplan CW, et al. Selective membrane disruption: mode of action of C16G2, a specifically targeted antimicrobial peptide. Antimicrobial agents and chemotherapy. 2011 Jul;55(7):3446-52. [Content Brief]
- [5]. Eckert R, et al. Targeted killing of Streptococcus mutans by a pheromone-guided "smart" antimicrobial peptide. Antimicrobial agents and chemotherapy. 2006 Nov;50(11):3651-7.
- [6]. Jiang W, et al. Antimicrobial Peptides as Novel Ecological Approaches to Caries Prevention. Drug design, development and therapy. 2026;20:592732.
