215802-15-6
215802-15-6
Chemical Structure
SB269652
- CAS No.: 215802-15-6
- Formula:C27H30N4O
- Molecular Weight:426.55
IUPAC Name: N-((1r,4r)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide
InChIKey: JGLGOAQPUQITLD-OGAOHHHESA-N
SMILES: O=C(C1=CC2=C(C=CC=C2)N1)N[C@H]3CC[C@H](CCN(CC4)CC5=C4C=CC(C#N)=C5)CC3
Biological Activity:
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SB269652 | 98.13% | SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology. | ||||||||||||||||||||
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References
- Silvano E, et al. The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors. Mol Pharmacol. 2010 Nov;78(5):925-34. [Content Brief]
- Lane JR, et al. A new mechanism of allostery in a G protein-coupled receptor dimer. Nat Chem Biol. 2014 Sep;10(9):745-52. [Content Brief]
- Presgraves SP, et al. Involvement of dopamine D(2)/D(3) receptors and BDNF in the neuroprotective effects of S32504 and pramipexole against 1-methyl-4-phenylpyridinium in terminally differentiated SH-SY5Y cells. Exp Neurol. 2004 Nov;190(1):157-70. [Content Brief]
