215803-78-4
Chemical Structure
SB-277011
Synonym(s): SB-277011A
- CAS No.: 215803-78-4
- Formula:C28H30N4O
- Molecular Weight:438.56
IUPAC Name: N-((1r,4r)-4-(2-(6-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)quinoline-4-carboxamide
InChIKey: OLWRVVHPJFLNPW-LSNLESRRSA-N
SMILES: O=C(C1=CC=NC2=CC=CC=C21)N[C@@H]3CC[C@H](CC3)CCN4CC5=C(CC4)C=C(C#N)C=C5
Biological Activity: SB-277011 (SB-277011A) is a highly selective dopamine D3 receptor antagonist. SB-277011 induces ejaculation delay by inhibiting the expulsion phase of ejaculation, without impairing ejaculatory secretion or erectile function. SB-277011 also prolongs the post-ejaculatory refractory period. SB-277011 has no effect on the spontaneous preference of male rats for females in the sexually receptive phase. SB-277011 is widely applicable to studies related to premature ejaculation[1][2].
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SB-277011 | SB-277011 (SB-277011A) is a highly selective dopamine D3 receptor antagonist. SB-277011 induces ejaculation delay by inhibiting the expulsion phase of ejaculation, without impairing ejaculatory secretion or erectile function. SB-277011 also prolongs the post-ejaculatory refractory period. SB-277011 has no effect on the spontaneous preference of male rats for females in the sexually receptive phase. SB-277011 is widely applicable to studies related to premature ejaculation. | |||||||||||||||||||||
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References
- [1]. dIaBeTIc RaTS S I U. Sb-277011, a selective dopamine D3 receptor antagonist, delays ejaculation in conscious and anesthetized rats[J]. Eur Urol, 2009, 8(4): 365.
- [2]. Clément P, et al. Delay of ejaculation induced by SB-277011, a selective dopamine D3 receptor antagonist, in the rat. J Sex Med. 2009;6(4):980-988. [Content Brief]
