215997-93-6
215997-93-6
Chemical Structure
PSB-15160
- CAS No.: 215997-93-6
- Formula:C17H12F2N2
- Molecular Weight:282.29
IUPAC Name: bis(5-fluoro-1H-indol-3-yl)methane
InChIKey: BEBUKYWOUXBVEE-UHFFFAOYSA-N
SMILES: FC=1C=CC=2NC=C(C2C1)CC3=CNC=4C=CC(F)=CC43
Biological Activity: PSB-15160 is a human GPR84 agonist with EC50 values of 0.0800 μM and 4.33 μM, and selectivity versus FFAR1, FFAR4, and arylhydrocarbon receptor. PSB-15160 exhibits biased agonism, ago-allosteric action, and structure-activity relationships differing between cAMP and β-arrestin assays. PSB-15160 shows increased stability relative to the lead structure 3,3'-diindolylmethane[1].
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PSB-15160 | PSB-15160 is a human GPR84 agonist with EC50 values of 0.0800 μM and 4.33 μM, and selectivity versus FFAR1, FFAR4, and arylhydrocarbon receptor. PSB-15160 exhibits biased agonism, ago-allosteric action, and structure-activity relationships differing between cAMP and β-arrestin assays. PSB-15160 shows increased stability relative to the lead structure 3,3'-diindolylmethane. | |||||||||||||||||||||
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