21618-99-5
21618-99-5
Chemical Structure
H77-77
- CAS No.: 21618-99-5
- Formula:C10H15NO
- Molecular Weight:165.24
IUPAC Name: 5-(2-aminopropyl)-2-methylphenol
InChIKey: XWLXNPMITZDCHL-UHFFFAOYSA-N
SMILES: OC1=CC(=CC=C1C)CC(N)C
Biological Activity: H77-77 is a selective MAO-A inhibitor with blood-brain barrier permeability, exhibiting an IC50 of 7.4 μM against rat MAO-A. H77-77 accumulates via uptake by serotonergic and noradrenergic neurons. H77-77 releases norepinephrine and serotonin from intracellular neuronal storage sites. H77-77 can be used in studies related to neurological disorders[1].
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H77-77 | H77-77 is a selective MAO-A inhibitor with blood-brain barrier permeability, exhibiting an IC50 of 7.4 μM against rat MAO-A. H77-77 accumulates via uptake by serotonergic and noradrenergic neurons. H77-77 releases norepinephrine and serotonin from intracellular neuronal storage sites. H77-77 can be used in studies related to neurological disorders. | |||||||||||||||||||||
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References
- [1]. Fagervall I, et al. Selective inhibition by 4,alpha-dimethyl-m-tyramine (H77/77) and 4-methyl-alpha-ethyl-m-tyramine (H75/12) of the monoamine oxidase within serotonergic and noradrenergic neurons in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. 1988 Aug;338(2):143-7. [Content Brief]
