2162120-87-6
2162120-87-6
Chemical Structure
(S,R,S)-AHPC-amido-C5-acid
- CAS No.: 2162120-87-6
- Formula:C29H40N4O6S
- Molecular Weight:572.72
IUPAC Name: 7-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptanoic acid
InChIKey: LYAMSRXTXVKKIC-TVZXLZGTSA-N
SMILES: O=C([C@H]1N(C[C@@H](C1)O)C([C@@H](NC(CCCCCC(O)=O)=O)C(C)(C)C)=O)NCC2=CC=C(C=C2)C3=C(N=CS3)C
Biological Activity: (S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(S,R,S)-AHPC-amido-C5-acid | 99.58% | (S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180). | ||||||||||||||||||||
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(S,R,S)-CO-C2-acid | 98.0% | (S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid) is a functionalized von-Hippel-Lindau (VHL) protein ligand and linker conjugate, which can be used in the research and development of PROTACs. | ||||||||||||||||||||
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(S,R,S)-AHPC-C4-COOH | 95.92% | (S,R,S)-AHPC-C4-COOH (VH032-C4-COOH) (linker 45) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-targeted PROTAC. | ||||||||||||||||||||
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VH032-C7-COOH | 99.92% | VH032-C7-COOH is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. VH032-C7-COOH contains an E3 ligase ligand and an alkyl linker with a terminal amine for conjugation of target protein ligands. | ||||||||||||||||||||
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(S,R,S)-AHPC-C5-NH2 | (S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader. | |||||||||||||||||||||
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(S,R,S)-AHPC-C5-NH2 dihydrochloride | 97.8% | (S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader. | ||||||||||||||||||||
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(S,R,S)-AHPC-CO-C9-acid | 95.00% | (S,R,S)-AHPC-CO-C9-acid is an E3 ligase ligand-linker conjugate that can be connected to the ligand for protein to form PROTACs. | ||||||||||||||||||||
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(S,R,S)-AHPC-C3-COOH | (S,R,S)-AHPC-C3-COOH (compound 28i) is a carboxylic acid derivative of the VHL E3 ubiquitin ligase ligand-Linker conjugate. (S,R,S)-AHPC-C3-COOH can be used to synthesize PROTACs. | |||||||||||||||||||||
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(S,R,S)-AHPC-amido-C7-acid | 98.71% | (S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design PROTACs. | ||||||||||||||||||||
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VH 032 amide-alkylC6-acid | VH 032 amide-alkylC6-acid ((S,R,S)-AHPC-CO-C6-COOH) is a VH032 analog that acts as a ligand for VHL, recruiting von Hippel-Lindau (VHL) protein. VH 032 amide-alkylC6-acid can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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(S,R,S)-AHPC-C5-NH2 hydrochloride | 95.0% | (S,R,S)-AHPC-C5-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-C5-NH2 hydrochloride can be used to synthesize PROTAC. | ||||||||||||||||||||
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