2163787-60-6
Chemical Structure
AMPAR modulator-12
- CAS No.: 2163787-60-6
- Formula:C19H22F2N2O4S2
- Molecular Weight:444.52
InChIKey: YNKNXJDSBMRLLJ-UHFFFAOYSA-N
SMILES: CN(C(COC1=C(C=C(C=C1F)SCCN(S(=O)(C2=CC=CC=C2)=O)C)F)=O)C
Biological Activity: AMPAR modulator-12 is a blood-brain barrier-permeable AMPAR positive allosteric modulator. AMPAR modulator-12 reduces NOX-1 expression, enhances AMPAR-mediated currents, promotes excitatory postsynaptic transmission and restores AMPAR function. AMPAR modulator-12 enhances excitatory and inhibitory synaptic transmission, reduces burst firing in the lateral habenula after withdrawal, and produces rapid and sustained antidepressant-like effects. AMPAR modulator-12 is applicable for the research of depression[1].
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AMPAR modulator-12 | AMPAR modulator-12 is a blood-brain barrier-permeable AMPAR positive allosteric modulator. AMPAR modulator-12 reduces NOX-1 expression, enhances AMPAR-mediated currents, promotes excitatory postsynaptic transmission and restores AMPAR function. AMPAR modulator-12 enhances excitatory and inhibitory synaptic transmission, reduces burst firing in the lateral habenula after withdrawal, and produces rapid and sustained antidepressant-like effects. AMPAR modulator-12 is applicable for the research of depression. | |||||||||||||||||||||
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