21653-40-7
Chemical Structure
Nα-Benzoyl-L-arginine 4-nitroanilide hydrochloride
- CAS No.: 21653-40-7
- Formula:C19H23ClN6O4
- Molecular Weight:434.88
IUPAC Name: (S)-N-(5-guanidino-1-((4-nitrophenyl)amino)-1-oxopentan-2-yl)benzamide hydrochloride
InChIKey: DEOKFPFLXFNAON-NTISSMGPSA-N
SMILES: O=C(C1=CC=CC=C1)N[C@@H](CCCNC(N)=N)C(NC2=CC=C(C=C2)[N+]([O-])=O)=O.Cl
Biological Activity: Nα-Benzoyl-L-arginine 4-nitroanilide hydrochloride is a chromogenic peptide substrate used for trypsin and tryptase-like serine proteases. Nα-Benzoyl-L-arginine 4-nitroanilide hydrochloride releases p-nitroaniline upon hydrolysis, which can be detected by absorbance. Nα-Benzoyl-L-arginine 4-nitroanilide hydrochloride can be used in studies of A1PI degradation[1][2][3].
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Nα-Benzoyl-L-arginine 4-nitroanilide hydrochloride | 99.92% | Nα-Benzoyl-L-arginine 4-nitroanilide hydrochloride is a chromogenic peptide substrate used for trypsin and tryptase-like serine proteases. Nα-Benzoyl-L-arginine 4-nitroanilide hydrochloride releases p-nitroaniline upon hydrolysis, which can be detected by absorbance. Nα-Benzoyl-L-arginine 4-nitroanilide hydrochloride can be used in studies of A1PI degradation. | ||||||||||||||||||||
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References
- [1]. Gogol M, et al. Inactivation of α1-proteinase inhibitor by Candida albicans aspartic proteases favors the epithelial and endothelial cell colonization in the presence of neutrophil extracellular traps. Acta biochimica Polonica. 2016;63(1):167-175.
- [2]. Chan AHW, et al. Pancreatic source of protease activity in the spontaneously hypertensive rat and its reduction during temporary food restriction. Microcirculation (New York, N.Y. : 1994). 2019 Aug;26(6):e12548.
- [3]. Costa CRC, et al. Edema Induced by a Crotalus durissus terrificus Venom Serine Protease (Cdtsp 2) Involves the PAR Pathway and PKC and PLC Activation. Int J Mol Sci. 2018 Aug 15;19(8):2405.
