2166487-23-4
Chemical Structure
Et-29
Synonym(s): NRD167
- CAS No.: 2166487-23-4
- Formula:C34H46N6O6S
- Molecular Weight:666.83
IUPAC Name: 6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide-3-13C-3,3-d2-2-15N-15N 1,1-dioxide
InChIKey: DCENHWUVADDCEN-VMPREFPWSA-N
SMILES: O=C(OCC1=CC=CC=C1)N[C@@H](CCCCNC(NCCC(OCC)=O)=S)C(N[C@H](C(NC(C)C)=O)CC2=CNC3=CC=CC=C23)=O
Biological Activity: Et-29 (NRD167) is a selective SIRT5 inhibitor. Et-29 increases the levels of total protein succinylation and citrate synthase succinylation in cells. Et-29 reduces serum CTX-I levels and blocks Ferroptosis by downregulating the SIRT5/ACSL4/LPCAT3/ALOX15 axis and restoring antioxidant defense. Et-29 decreases bone resorption and improves trabecular bone mass and microarchitecture. Et-29 is applicable for research related to osteoporosis and hepatocellular carcinoma[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Et-29 | 99.89% | Et-29 (NRD167) is a selective SIRT5 inhibitor. Et-29 increases the levels of total protein succinylation and citrate synthase succinylation in cells. Et-29 reduces serum CTX-I levels and blocks Ferroptosis by downregulating the SIRT5/ACSL4/LPCAT3/ALOX15 axis and restoring antioxidant defense. Et-29 decreases bone resorption and improves trabecular bone mass and microarchitecture. Et-29 is applicable for research related to osteoporosis and hepatocellular carcinoma. | ||||||||||||||||||||
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References
- [1]. Zhu K, et al. The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction. Cell communication and signaling : CCS. 2025 Jan 14;23(1):26.
- [2]. Rajabi N, et al. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angewandte Chemie (International ed. in English). 2017 Nov 20;56(47):14836-14841. [Content Brief]
- [3]. Xue P, et al. Arachidonic acid induces ferroptosis in hepatocellular carcinoma via the SIRT5-ACSL4/LPCAT3/ALOX15 axis, leading to lipid peroxidation and mitochondrial dysfunction. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2025 Nov 25;148:157450. [Content Brief]
- [4]. Cao H, et al. Sirtuin 5 inhibits mitochondrial metabolism in liver cancer cells and promotes apoptosis by mediating the desuccinylation of CS. Frontiers in immunology. 2025;16:1560989.
