2169905-97-7
Chemical Structure
Vemtoberant mesylate
Synonym(s): APD418 mesylate
- CAS No.: 2169905-97-7
- Formula:C30H41N3O11S3
- Molecular Weight:715.86
IUPAC Name: 1-ethyl-3-(((R)-3-(((S)-2-hydroxy-3-(3-(methylsulfonyl)phenoxy)propyl)amino)-1-oxa-8-azaspiro[4.5]decan-8-yl)sulfonyl)quinolin-4(1H)-one methanesulfonate
InChIKey: HFSUUDYRXDNDOR-NSLUPJTDSA-N
SMILES: CS(C1=CC=CC(OC[C@@H](O)CN[C@@H]2CC3(OC2)CCN(CC3)S(=O)(C4=CN(CC)C5=CC=CC=C5C4=O)=O)=C1)(=O)=O.CS(O)(=O)=O
Biological Activity: Vemtoberant (APD418) mesylate is a β3-adrenergic receptor (β3-AR) antagonist with a human Ki of 8.2 nM, and exhibits 400- to 600-fold selectivity over human β1-AR and β2-AR. Vemtoberant mesylate attenuates β3-AR-mediated cardiac inhibition. Vemtoberant mesylate can be used for the research of systolic heart failure[1].
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Vemtoberant mesylate | Vemtoberant (APD418) mesylate is a β3-adrenergic receptor (β3-AR) antagonist with a human Ki of 8.2 nM, and exhibits 400- to 600-fold selectivity over human β1-AR and β2-AR. Vemtoberant mesylate attenuates β3-AR-mediated cardiac inhibition. Vemtoberant mesylate can be used for the research of systolic heart failure. | |||||||||||||||||||||
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