2172820-14-1
2172820-14-1
Chemical Structure
(S,R,S)-AHPC-PEG5-COOH
Synonym(s): VH032-PEG5-COOH; VHL Ligand-Linker Conjugates 16; E3 Ligase Ligand-Linker Conjugates 58
- CAS No.: 2172820-14-1
- Formula:C36H54N4O11S
- Molecular Weight:750.90
IUPAC Name: (S)-21-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-22,22-dimethyl-19-oxo-4,7,10,13,16-pentaoxa-20-azatricosanoic acid
InChIKey: YDOJYEPMGKGKQV-ZLWRCJDJSA-N
SMILES: O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CCOCCOCCOCCOCCOCCC(O)=O)=O)=O)C[C@H](O)C3
Biological Activity: (S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(S,R,S)-AHPC-PEG5-COOH | 99.79% | (S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology. | ||||||||||||||||||||
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(S,R,S)-AHPC-C2-PEG4-N3 | 97.63% | (S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-C2-PEG4-N3 can be used in the synthesis of vRucaparib-TP4 (HY-130647). vRucaparib-TP4 a highly potent PARP1 degrader with a half-maximal degrading concentration (DC50) of 82 nM. (S,R,S)-AHPC-C2-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | ||||||||||||||||||||
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(S,R,S)-AHPC-PEG5-Boc | (S,R,S)-AHPC-PEG5-Boc is a E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for Cdc20 degrader CP5V. | |||||||||||||||||||||
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(S,R,S)-AHPC-PEG3-propionic acid | (S,R,S)-AHPC-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. | |||||||||||||||||||||
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(S,R,S)-AHPC-PEG2-acid | 98.88% | (S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. | ||||||||||||||||||||
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AHPC-PEG6-CH2COOH | AHPC-PEG6-CH2COOH is an E3 ligase ligand-linker conjugate that incorporates a VHL ligand and 6-unit PEG linker (HY-122702). AHPC-PEG6-CH2COOH can be used for synthesis of PROTAC CMP98 (HY-136257). | |||||||||||||||||||||
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(S,R,S)-AHPC-amide-PEG5-C2-azide | (S,R,S)-AHPC-amide-PEG5-C2-azide (VH032-CO-(CH2)2-(O-CH2-CH2)5-azide) is a PROTAC linker that can be used to design PROTACs. | |||||||||||||||||||||
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(S,R,R)-VH032-CO-PEG4-NH2 | (S,R,R)-VH032-CO-PEG4-NH2 is a VHL ligand-linker conjugate. (S,R,R)-VH032-CO-PEG4-NH2 can be used to synthesize STING PROTAC degraders, such as UNC8900 (HY-158047). (S,R,R)-VH032-CO-PEG4-NH2 is applicable to the research of renal cell carcinoma. | |||||||||||||||||||||
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(S,R,S)-AHPC-PEG4-acid | (S,R,S)-AHPC-PEG4-acid is a synthetic PROTAC ligand that binds the E3 ligase ligand to the PEG4 arm, thereby enhancing PROTAC drug research and discovery. | |||||||||||||||||||||
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(S,R,S)-Ahpc-PEG6-azide | (S, R, S)-AHPC-PEG6-Azide is a click chemistry PROTAC linker that incorporates an E3 ligase ligand with a PEG6 arm to empower PROTAC research & discovery. The hydrophilic PEG spacer increases the solubility of a compound in aqueous media. Azide enables click chemistry with alkyne, DBCO, or BCN molecule. | |||||||||||||||||||||
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(S,R,S)-AHPC-CO-C-PEG5-amine hydrochloride | (S,R,S)-AHPC-CO-C-PEG5-amine hydrochloride is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. (S,R,S)-AHPC-CO-C-PEG5-amine hydrochloride can be used to synthesize PROTAC. | |||||||||||||||||||||
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