2172879-84-2
2172879-84-2
Chemical Structure
EGFR-IN-160
- CAS No.: 2172879-84-2
- Formula:C15H12N2O4
- Molecular Weight:284.27
InChIKey: AZXGVYYXWSGGHS-UHFFFAOYSA-N
SMILES: COC1=CC(C2=CC(C3=CC=CO3)=NC(O)=N2)=CC=C1O
Biological Activity: EGFR-IN-160 (Compound R12) is an EGFR inhibitor (IC50 values are 1.62, 0.49 and 0.98 μM for EGFRWT, EGFRT790M and EGFRL858R/T790M/C797S, respectively). EGFR-IN-160 induces G2/M and S phase arrest and apoptosis in NCI-H522 cells, and has anticancer activity. EGFR-IN-160 has antioxidant effects against DPPH (IC50: 12.11 µM) and H2O2 (IC50: 8.89 µM)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EGFR-IN-160 | EGFR-IN-160 (Compound R12) is an EGFR inhibitor (IC50 values are 1.62, 0.49 and 0.98 μM for EGFRWT, EGFRT790M and EGFRL858R/T790M/C797S, respectively). EGFR-IN-160 induces G2/M and S phase arrest and apoptosis in NCI-H522 cells, and has anticancer activity. EGFR-IN-160 has antioxidant effects against DPPH (IC50: 12.11 µM) and H2O2 (IC50: 8.89 µM). | |||||||||||||||||||||
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