2173557-02-1
2173557-02-1
Chemical Structure
RIPK1-IN-11
- CAS No.: 2173557-02-1
- Formula:C23H24N4O4S
- Molecular Weight:452.53
IUPAC Name: tetrahydro-2H-pyran-4-yl (5-(2-(cyclopropanecarboxamido)benzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate
InChIKey: CWGYJOVAHWYDTO-UHFFFAOYSA-N
SMILES: O=C(OC1CCOCC1)NC2=CC(C3=CC=C4N=C(NC(C5CC5)=O)SC4=C3)=CN=C2C
Biological Activity: RIPK1-IN-11 is a potent and orally active RIPK1 inhibitor (Kd=9.2 nM; IC50=67 nM). RIPK1-IN-11 inhibits necroptosis in both human and mouse cells (EC50=17-30 nM). Anti-inflammatory activity[1].
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RIPK1-IN-11 | RIPK1-IN-11 is a potent and orally active RIPK1 inhibitor (Kd=9.2 nM; IC50=67 nM). RIPK1-IN-11 inhibits necroptosis in both human and mouse cells (EC50=17-30 nM). Anti-inflammatory activity. | |||||||||||||||||||||
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