2174938-70-4
2174938-70-4
Chemical Structure
CCR4-351
- CAS No.: 2174938-70-4
- Formula:C24H27Cl2N7O
- Molecular Weight:500.42
IUPAC Name: 1-((R)-1-(2,4-dichlorophenyl)ethyl)-6-(3-((R)-1-(2-hydroxyethyl)piperidin-3-yl)azetidin-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile
InChIKey: PNCGVFJZWKHMCL-CVEARBPZSA-N
SMILES: [H][C@@]1(CCCN(C1)CCO)C2CN(C2)C3=CN=C(C4=N3)C(C#N)=NN4[C@H](C)C5=CC=C(C=C5Cl)Cl
Biological Activity: CCR4-351 is an orally active, potent and selective CCR4 antagonist. CCR4-351, featuring a novel piperidinyl-azetidine motif, has IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 has antitumor activity[1].
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CCR4-351 | 98.95% | CCR4-351 is an orally active, potent and selective CCR4 antagonist. CCR4-351, featuring a novel piperidinyl-azetidine motif, has IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 has antitumor activity. | ||||||||||||||||||||
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