2177311-29-2
2177311-29-2
Chemical Structure
HF51116
- CAS No.: 2177311-29-2
- Formula:C29H46N8O
- Molecular Weight:522.73
IUPAC Name: L-leucine-2-d
InChIKey: AMGQQWNQWHMPHG-MHZLTWQESA-N
SMILES: N=C(N)NCCC[C@H](NCC1=CC=CC=N1)C(NCC2=CC=C(C=C2)CNCCCNC3CCCCC3)=O
Biological Activity: HF51116 is a CXCR4 antagonist. HF51116 inhibits calcium influx/mobilization. HF51116 mobilizes HSPC and AML from bone marrow to peripheral blood in mice/monkeys, and enhances G-CSF-induced cell mobilization. HF51116 inhibits HIV-1 infection, lacks cytotoxicity in cells expressing CXCR4, and when combined with Cytarabine (HY-13605) reduces AML burden and prolongs survival in AML xenograft models[1][2][3].
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HF51116 | HF51116 is a CXCR4 antagonist. HF51116 inhibits calcium influx/mobilization. HF51116 mobilizes HSPC and AML from bone marrow to peripheral blood in mice/monkeys, and enhances G-CSF-induced cell mobilization. HF51116 inhibits HIV-1 infection, lacks cytotoxicity in cells expressing CXCR4, and when combined with Cytarabine (HY-13605) reduces AML burden and prolongs survival in AML xenograft models. | |||||||||||||||||||||
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References
- [1]. Fang X, et al. A novel small molecule CXCR4 antagonist potently mobilizes hematopoietic stem cells in mice and monkeys. Stem cell research & therapy. 2021 Jan 07;12(1):17.
- [2]. Fang X, et al. A fragment integrational approach to GPCR inhibition: Identification of a high affinity small molecule CXCR4 antagonist. European journal of medicinal chemistry. 2022 Mar 05;231:114150. [Content Brief]
- [3]. Huang Y, et al. A novel small molecule CXCR4 antagonist improves anticancer therapy by blocking the interaction of malignant cells with their associated niches[J]. 2024.
