2180287-51-6
Chemical Structure
(Rac)-Lateritin
- CAS No.: 2180287-51-6
- Formula:C15H19NO3
- Molecular Weight:261.32
IUPAC Name: 3-benzyl-6-isopropyl-4-methylmorpholine-2,5-dione
InChIKey: YOKBTBNVNCFOBF-UHFFFAOYSA-N
SMILES: O=C1OC(C(=O)N(C)C1CC=2C=CC=CC2)C(C)C
Biological Activity: (Rac)-Lateritin is an acyl-CoA:cholesterol acyltransferase (ACAT/SOAT) inhibitor, with IC50 values of 5.7 μM and 5.6 μM in rat liver, respectively. (Rac)-Lateritin exerts time-dependent irreversible enzyme inhibition that persists even after microsomal washing. (Rac)-Lateritin inhibits cholesterol ester formation in macrophages without altering triglyceride synthesis or other steps in oxidized low-density lipoprotein metabolism. (Rac)-Lateritin inhibits the growth of cancer cells, Gram-positive bacteria, and Candida albicans. (Rac)-Lateritin can be used in studies related to atherosclerosis, human solid tumors, mouse lymphocytic leukemia, as well as fungal and bacterial infections[1][2][3].
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(Rac)-Lateritin | (Rac)-Lateritin is an acyl-CoA:cholesterol acyltransferase (ACAT/SOAT) inhibitor, with IC50 values of 5.7 μM and 5.6 μM in rat liver, respectively. (Rac)-Lateritin exerts time-dependent irreversible enzyme inhibition that persists even after microsomal washing. (Rac)-Lateritin inhibits cholesterol ester formation in macrophages without altering triglyceride synthesis or other steps in oxidized low-density lipoprotein metabolism. (Rac)-Lateritin inhibits the growth of cancer cells, Gram-positive bacteria, and Candida albicans. (Rac)-Lateritin can be used in studies related to atherosclerosis, human solid tumors, mouse lymphocytic leukemia, as well as fungal and bacterial infections. | |||||||||||||||||||||
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References
- [1]. Hasumi K, et al. Lateritin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Gibberella lateritium IFO 7188. The Journal of antibiotics. 1993 Dec;46(12):1782-7. [Content Brief]
- [2]. Bhattacharjee P, et al. Targeting Sterol -Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential. Journal of medicinal chemistry. 2022 Dec 22;65(24):16062-16098. [Content Brief]
- [3]. Pettit RK, et al. Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture. Planta medica. 2010 Mar;76(5):500-1. [Content Brief]
