2185855-51-8
Chemical Structure
SCR-4026
- CAS No.: 2185855-51-8
- Formula:C14H12Cl2N2O2
- Molecular Weight:311.16
IUPAC Name: 4-((2-amino-4,6-dichlorophenoxy)methyl)benzamide
InChIKey: WDGFRIHJXKWMFP-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(COC2=C(N)C=C(Cl)C=C2Cl)C=C1)N
Biological Activity: SCR-4026 is a neuroprotective agent with blood-brain barrier penetration ability. SCR-4026 exerts neuroprotective effects by disrupting the interaction between neuronal nNOS and PSD9, with an IC50 of 6.3 μM. SCR-4026 alleviates N-methyl-D-aspartate (NMDA)-induced excitotoxic damage in primary cortical neurons, and also protects neurons in the oxygen-glucose deprivation (OGD) model. SCR-4026 can reduce the cerebral infarct volume in the rat middle cerebral artery occlusion (MCAO) reperfusion model. SCR-4026 can be used for the study of stroke[1].
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SCR-4026 | SCR-4026 is a neuroprotective agent with blood-brain barrier penetration ability. SCR-4026 exerts neuroprotective effects by disrupting the interaction between neuronal nNOS and PSD9, with an IC50 of 6.3 μM. SCR-4026 alleviates N-methyl-D-aspartate (NMDA)-induced excitotoxic damage in primary cortical neurons, and also protects neurons in the oxygen-glucose deprivation (OGD) model. SCR-4026 can reduce the cerebral infarct volume in the rat middle cerebral artery occlusion (MCAO) reperfusion model. SCR-4026 can be used for the study of stroke. | |||||||||||||||||||||
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