2187395-66-8
2187395-66-8
Chemical Structure
LY3358966
- CAS No.: 2187395-66-8
- Formula:C43H49F2N5O6S
- Molecular Weight:801.94
InChIKey: AMOHQOVBWMGTAS-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(CCC2=C(C=C(NC(C3=C(NC(C4=CC=CC(CN5CCN(CC5(C)C)C(NCCCCO)=O)=C4)=O)SC6=C3CCCC6)=O)C=C2F)F)C=C1)O
Biological Activity: LY3358966 is an orally active sodium-dependent phosphate cotransporter 2b (NPT2b) inhibitor with a human IC50 of 32.4 nM, mouse IC50 of 43.9 nM, and rat of IC50 26.8 nM. LY3358966 inhibits NPT2b-mediated intestinal phosphate transport, decreases acute phosphate uptake into plasma, and increases fecal phosphate excretion. LY3358966 can be used for the research of renal disease[1].
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LY3358966 | LY3358966 is an orally active sodium-dependent phosphate cotransporter 2b (NPT2b) inhibitor with a human IC50 of 32.4 nM, mouse IC50 of 43.9 nM, and rat of IC50 26.8 nM. LY3358966 inhibits NPT2b-mediated intestinal phosphate transport, decreases acute phosphate uptake into plasma, and increases fecal phosphate excretion. LY3358966 can be used for the research of renal disease. | |||||||||||||||||||||
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