2193085-94-6
2193085-94-6
Chemical Structure
NCGC1481
- CAS No.: 2193085-94-6
- Formula:C21H23N7O
- Molecular Weight:389.45
InChIKey: IALDYVNFZAPNJV-UHFFFAOYSA-N
SMILES: CN1N=CC(C2=CN3C(C=C2OC)=NC=C3C4=CC=CC(NC5CNCC5)=N4)=C1
Biological Activity: NCGC1481 is an inhibitor of FLT3, IRAK1, and IRAK4, with IC50 values of <0.5 nM, 22.6 nM, and 0.8 nM, respectively. NCGC1481 can effectively overcome the adaptive resistance of leukemia cells to FLT3 inhibitors and has antileukemic activity[1].
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NCGC1481 | NCGC1481 is an inhibitor of FLT3, IRAK1, and IRAK4, with IC50 values of <0.5 nM, 22.6 nM, and 0.8 nM, respectively. NCGC1481 can effectively overcome the adaptive resistance of leukemia cells to FLT3 inhibitors and has antileukemic activity. | |||||||||||||||||||||
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