219793-20-1
Chemical Structure
Furohyperforin
- CAS No.: 219793-20-1
- Formula:C35H52O5
- Molecular Weight:552.78
IUPAC Name: (2S,3aS,5S,6R,7R)-2-(2-hydroxypropan-2-yl)-7-isobutyryl-6-methyl-5,9-bis(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)-2,3,4,5,6,7-hexahydro-8H-3a,7-methanocycloocta[b]furan-8,10-dione
InChIKey: SUOQGZCCNGMYHT-WYSBIKLGSA-N
SMILES: O=C1[C@@]23C(O[C@@H](C3)C(C)(O)C)=C(C([C@@]1([C@@](C)([C@H](C2)C/C=C(C)\C)CC/C=C(C)/C)C(C(C)C)=O)=O)C/C=C(C)\C
Biological Activity: Furohyperforin is a natural product isolated from Hypericum perforatum L., possessing neuroprotective and antidepressant activities. Furohyperforin acts as an NLRP3 inflammasome inhibitor and also exhibits inhibitory effects on recombinant CYP3A4. Furohyperforin exerts neuroprotective effects against corticosterone-induced neuronal damage. Furohyperforin inhibits the NLRP3 inflammasome cascade and its downstream IL‑1β and GSDMD signaling pathways, and also reduces serum corticosterone levels in mice, regulating HPA axis function. Furohyperforin is applicable for depression-related research[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Furohyperforin | Furohyperforin is a natural product isolated from Hypericum perforatum L., possessing neuroprotective and antidepressant activities. Furohyperforin acts as an NLRP3 inflammasome inhibitor and also exhibits inhibitory effects on recombinant CYP3A4. Furohyperforin exerts neuroprotective effects against corticosterone-induced neuronal damage. Furohyperforin inhibits the NLRP3 inflammasome cascade and its downstream IL‑1β and GSDMD signaling pathways, and also reduces serum corticosterone levels in mice, regulating HPA axis function. Furohyperforin is applicable for depression-related research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Lee JY, et al. Hyperforin and its analogues inhibit CYP3A4 enzyme activity. Phytochemistry. 2006 Dec;67(23):2550-60.
- [2]. Pan XG, et al. NOD-like receptor protein 3 inhibitors in St. John's wort and their potential antidepressant effects. International journal of biological macromolecules. 2025 May;306(Pt 4):141721.
- [3]. Galeotti N, et al. St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activity. Biochemical pharmacology. 2010 May 01;79(9):1327-36.
- [4]. Jensen AG, et al. Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity. Life sciences. 2001 Feb 23;68(14):1593-605.
- [5]. Zeng YR, et al. Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum. Journal of Asian natural products research. 2021 Jan 2;23(1):73-81.
