219986-78-4
Chemical Structure
Bromo-dragonFLY hydrochloride
- CAS No.: 219986-78-4
- Formula:C13H13BrClNO2
- Molecular Weight:330.60
IUPAC Name: 1H-benzo[d][1,2,3]triazole compound with pyrrolidine (1:1)
InChIKey: YDIDKNSMQNPNFC-UHFFFAOYSA-N
SMILES: BrC1=C2OC=CC2=C(CC(C)N)C3=C1C=CO3.Cl
Biological Activity: Bromo-DragonFLY hydrochloride is an orally active benzodifuran psychoactive substance with hallucinogen-related activity. Bromo-dragonFLY hydrochloride is a 5-HT2A receptor agonist and MAO-A inhibitor that activates the Gαq-PLC-β/IP1/calcium signaling pathway and targets serotonin subtypes associated with hallucinogenic effects. Bromo-dragonFLY hydrochloride produces full substitution for the LSD stimulus in LSD-trained rats in drug discrimination experiments, induces head-twitch responses in mice, and blocks hERG potassium channels. Bromo-dragonFLY hydrochloride can be used in research related to neurological diseases[1][2][3][4][5][6].
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Bromo-dragonFLY hydrochloride | Bromo-DragonFLY hydrochloride is an orally active benzodifuran psychoactive substance with hallucinogen-related activity. Bromo-dragonFLY hydrochloride is a 5-HT2A receptor agonist and MAO-A inhibitor that activates the Gαq-PLC-β/IP1/calcium signaling pathway and targets serotonin subtypes associated with hallucinogenic effects. Bromo-dragonFLY hydrochloride produces full substitution for the LSD stimulus in LSD-trained rats in drug discrimination experiments, induces head-twitch responses in mice, and blocks hERG potassium channels. Bromo-dragonFLY hydrochloride can be used in research related to neurological diseases. | |||||||||||||||||||||
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References
- [1]. Deventer MH, et al. Off-target activity of NBOMes and NBOMe analogs at the µ opioid receptor. Archives of Toxicology. 2023 May;97(5):1367-84.
- [2]. Noga M, et al. ADME of Bromo-DragonFLY as an example of a new psychoactive substance (NPS) - application of in Silico methods for prediction: absorption, distribution, metabolism and excretion. Scientific reports. 2025 Jul 02;15(1):22949.
- [3]. Rickli A, et al. Pharmacological profile of novel psychoactive benzofurans. British journal of pharmacology. 2015 Jul;172(13):3412-25. [Content Brief]
- [4]. Halberstadt AL, et al. Comparison of the behavioral responses induced by phenylalkylamine hallucinogens and their tetrahydrobenzodifuran ("FLY") and benzodifuran ("DragonFLY") analogs. Neuropharmacology. 2019 Jan;144:368-376. [Content Brief]
- [5]. Pottie E, et al. Live cell luminescence-based Gαq-PLC-β interaction assay: Development and application at the serotonin 5-HT2A receptor. Pharmacological Research. 2026 Jan 10:108094.
- [6]. Noga M, et al. Toxicity of Bromo-DragonFLY as a New Psychoactive Substance: Application of Methods for the Prediction of Key Toxicological Parameters Important to Clinical and Forensic Toxicology. Chemical research in toxicology. 2024 Nov 18;37(11):1821-1842.
