220334-14-5
Chemical Structure
Angstrom6
Synonym(s): A6 Peptide
- CAS No.: 220334-14-5
- Formula:C39H62N10O15
- Molecular Weight:910.97
InChIKey: YUDSEXRLRQZDOS-PJYAFMLMSA-N
SMILES: O=C(N(CCC1)[C@@H]1C(N[C@@H](CCC(O)=O)C(N[C@H](C(N)=O)CCC(O)=O)=O)=O)[C@H](CCC2)N2C([C@H](CO)NC([C@H](CO)NC([C@H](CCC3)N3C([C@@H](NC(C)=O)CCCCN)=O)=O)=O)=O
Biological Activity: Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling[1][2].
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Angstrom6 | 99.96% | Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling. | ||||||||||||||||||||
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References
- [1]. Ghamande SA, et al. A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol Oncol. 2008;111(1):89-94. [Content Brief]
- [2]. Finlayson M. Modulation of CD44 Activity by A6-Peptide. Front Immunol. 2015;6:135. Published 2015 Mar 30. [Content Brief]
