2204249-82-9
2204249-82-9
Chemical Structure
γ-Secretase modulator 12
- CAS No.: 2204249-82-9
- Formula:C25H23N3O2
- Molecular Weight:397.47
IUPAC Name: 5-(8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl)-2-ethylisoindolin-1-one
InChIKey: BNQOGECWBFADFA-UHFFFAOYSA-N
SMILES: O=C1C2=C(CN1CC)C=C(C3=C(C)N=C4C(OCC5=CC=CC=C5)=CC=CN43)C=C2
Biological Activity: γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM). γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice[1].
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γ-Secretase modulator 12 | γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM). γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice. | |||||||||||||||||||||
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