2205015-77-4
Chemical Structure
Multitarget AD inhibitor-1
- CAS No.: 2205015-77-4
- Formula:C29H38N2O
- Molecular Weight:430.62
IUPAC Name: 1-((3-(tert-butyl)benzyl)amino)-3-((3,3-diphenylpropyl)amino)propan-2-ol
InChIKey: QEVPSMYJQDNACG-UHFFFAOYSA-N
SMILES: OC(CNCC1=CC=CC(C(C)(C)C)=C1)CNCCC(C2=CC=CC=C2)C3=CC=CC=C3
Biological Activity:
Multitarget AD inhibitor-1 is a selective and reversible butyrylcholinesterase (BuChE) inhibitor with IC50s of 7.22 μM and 1.55 μM for hBuChE and eqBuChE (BuChE from equine serum), respectively. Multitarget AD inhibitor-1 inhibits β-secretase (IC50hBACE-1=41.60 μM), amyloid β aggregation (IC50Aβ=3.09 μM), tau aggregation. Multitarget AD inhibitor-1, a diphenylpropylamine derivative, has the potential for multifunctional disease-modifying anti-Alzheimer’s research[1].
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Multitarget AD inhibitor-1 | Multitarget AD inhibitor-1 is a selective and reversible butyrylcholinesterase (BuChE) inhibitor with IC50s of 7.22 μM and 1.55 μM for hBuChE and eqBuChE (BuChE from equine serum), respectively. Multitarget AD inhibitor-1 inhibits β-secretase (IC50hBACE-1=41.60 μM), amyloid β aggregation (IC50Aβ=3.09 μM), tau aggregation. Multitarget AD inhibitor-1, a diphenylpropylamine derivative, has the potential for multifunctional disease-modifying anti-Alzheimer’s research. |
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