2206660-95-7
Chemical Structure
Zopocianine sodium
Synonym(s): OTL-0078 sodium; OTL78 sodium
- CAS No.: 2206660-95-7
- Formula:C74H92N7NaO27S4
- Molecular Weight:1662.80
InChIKey: SERYXKNRMMYZTJ-JVONNQFASA-M
SMILES: O=S(CCCCN1C2=CC=C(C=C2C(/C1=C/C=C3C(OC4=CC=C(C[C@H](NC([C@H](CC5=CC=CC=C5)NC(CCOCCOCCNC(CC[C@H](NC(N[C@@H](CCC(O[Na])=O)C(O)=O)=O)C(O)=O)=O)=O)=O)C(O)=O)C=C4)=C(/C=C\C6=[N+](CCCCS(=O)([O-])=O)C7=CC=C(C=C7C6(C)C)S(=O)(O)=O)CCC/3)(C)C)S(=O)(O)=O)(O)=O
Biological Activity: Zopocianine sodium (OTL-0078 sodium; OTL78 sodium) is a near-infrared optical probe targeting PSMA. Zopocianine sodium binds to PSMA on the surface of PSMA-expressing cells, enters cells via receptor-mediated endocytosis, and accumulates in acidic endosomes. Zopocianine sodium selectively accumulates in PSMA-positive cancer tissues and enables the detection of small tumors, primary prostate tumors, and locoregional metastases. Zopocianine sodium helps achieve negative tumor surgical margins during fluorescence-guided surgery. Zopocianine sodium is applicable to research related to prostate cancer[1].
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Zopocianine sodium | Zopocianine sodium (OTL-0078 sodium; OTL78 sodium) is a near-infrared optical probe targeting PSMA. Zopocianine sodium binds to PSMA on the surface of PSMA-expressing cells, enters cells via receptor-mediated endocytosis, and accumulates in acidic endosomes. Zopocianine sodium selectively accumulates in PSMA-positive cancer tissues and enables the detection of small tumors, primary prostate tumors, and locoregional metastases. Zopocianine sodium helps achieve negative tumor surgical margins during fluorescence-guided surgery. Zopocianine sodium is applicable to research related to prostate cancer. | |||||||||||||||||||||
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