2206788-99-8
Chemical Structure
CCR4 antagonist 2
- CAS No.: 2206788-99-8
- Formula:C26H28Cl2N6O
- Molecular Weight:511.45
IUPAC Name: 1-((R)-1-(2,4-dichlorophenyl)ethyl)-6-((4S,5R)-4-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-5-methylcyclohex-1-en-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile
InChIKey: KQZLRWGGWXJPOS-NLFPWZOASA-N
SMILES: ClC(C=C(Cl)C=C1)=C1[C@@H](C)N2N=C(C#N)C3=C2N=C(C4=CC[C@H](N5[C@H](CO)CCC5)[C@H](C)C4)C=N3
Biological Activity: CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively[1].
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CCR4 antagonist 2 | CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively. | |||||||||||||||||||||
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