2206807-06-7
Chemical Structure
Periplanetasin-4
- CAS No.: 2206807-06-7
- Formula:C70H110N20O15S
- Molecular Weight:1503.81
InChIKey: ZZZSRXWINZRUKC-LTGNONLESA-N
SMILES: O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CC=C(C=C2)O)C(NCC(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CS)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(NCC(N4[C@@H](CCC4)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
Biological Activity: Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach (Periplaneta americana). Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and p21. Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candida albicans ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis[1][2].
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Periplanetasin-4 | Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach (Periplaneta americana). Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and p21. Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candida albicans ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis. | |||||||||||||||||||||
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References
- [1]. Yoon IN, et al. The American cockroach peptide periplanetasin-4 inhibits Clostridium difficile toxin A-induced cell toxicities and inflammatory responses in the mouse gut. J Pept Sci. 2017 Nov;23(11):833-839. [Content Brief]
- [2]. Lee H, et al. Periplanetasin-4, a novel antimicrobial peptide from the cockroach, inhibits communications between mitochondria and vacuoles. Biochem J. 2019 Apr 26;476(8):1267-1284. [Content Brief]
