220965-54-8
220965-54-8
Chemical Structure
H111-H7
- CAS No.: 220965-54-8
- Formula:C13H10ClNO3S2
- Molecular Weight:327.81
InChIKey: RDTHPXUYMXYOOO-UHFFFAOYSA-N
SMILES: CC(C1=CC([N+]([O-])=O)=C(S1)SCC2=CC=C(C=C2)Cl)=O
Biological Activity: H111-H7 is a WW domain containing E3 ubiquitin 27 protein ligase 2 (WWP2) inhibitor with a KD of 717 nM. H111-H7 inhibits WWP2 expression, restores the succinate dehydrogenase complex subunit C (SDHC) level, and defers the acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition in unilateral kidney ischemia–reperfusion (UIR) mice. H111-H7 can be used for AKI-to-CKD transition research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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H111-H7 | 98.14% | H111-H7 is a WW domain containing E3 ubiquitin 27 protein ligase 2 (WWP2) inhibitor with a KD of 717 nM. H111-H7 inhibits WWP2 expression, restores the succinate dehydrogenase complex subunit C (SDHC) level, and defers the acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition in unilateral kidney ischemia–reperfusion (UIR) mice. H111-H7 can be used for AKI-to-CKD transition research. | ||||||||||||||||||||
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