220991-20-8
220991-20-8
Chemical Structure
Lumiracoxib
Synonym(s): COX-189
- CAS No.: 220991-20-8
- Formula:C15H13ClFNO2
- Molecular Weight:293.72
IUPAC Name: 2-(2-((2-chloro-6-fluorophenyl)amino)-5-methylphenyl)acetic acid
InChIKey: KHPKQFYUPIUARC-UHFFFAOYSA-N
SMILES: O=C(O)CC1=CC(C)=CC=C1NC2=C(F)C=CC=C2Cl
Biological Activity: Lumiracoxib is a potent,selective and orally active COX-2 inhibitor with a Ki value of 0.06?μM[1]. Lumiracoxib acts as a nonselective NSAID with?anti-inflammatory, analgesic and antipyretic activities. Lumiracoxib can be used for osteoarthritis and bone cancer research[1][2].
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Lumiracoxib | 99.56% | Lumiracoxib is a potent,selective and orally active COX-2 inhibitor with a Ki value of 0.06?μM. Lumiracoxib acts as a nonselective NSAID with?anti-inflammatory, analgesic and antipyretic activities. Lumiracoxib can be used for osteoarthritis and bone cancer research. | ||||||||||||||||||||
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Lumiracoxib (Standard) | ≥98% | Lumiracoxib (Standard) is the analytical standard of Lumiracoxib. This product is intended for research and analytical applications. Lumiracoxib is a potent,selective and orally active COX-2 inhibitor with a Ki value of 0.06 μM. Lumiracoxib acts as a nonselective NSAID with anti-inflammatory, analgesic and antipyretic activities. Lumiracoxib can be used for osteoarthritis and bone cancer research. | ||||||||||||||||||||
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References
- [1]. Ronald Esser, et al. Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. Br J Pharmacol. 2005 Feb;144(4):538-50. [Content Brief]
- [2]. Alyson Fox, et al. Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat. Pain [Content Brief]
