221010-51-1
Chemical Structure
Uridine 5'-O-thiodiphosphate
Synonym(s): UDP-β-S
- CAS No.: 221010-51-1
- Formula:C9H14N2O11P2S
- Molecular Weight:420.23
InChIKey: HFPQTPQWHHTLHT-XVFCMESISA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C=CC(NC2=O)=O)O[C@@H]1COP(OP(O)(S)=O)(O)=O
Biological Activity: Uridine 5'-O-thiodiphosphate (UDP-β-S) is a P2Y6 receptor agonist with an EC50 of 25 nM. Uridine 5'-O-thiodiphosphate resists degradation by extracellular nucleotidases and stimulates the accumulation of inositol phosphates. Uridine 5'-O-thiodiphosphate stimulates contractile responses in endothelium-denuded rat mesenteric arteries. As a mitogen, Uridine 5'-O-thiodiphosphate stimulates DNA synthesis, [3H] thymidine incorporation, protein synthesis, [3H]leucine incorporation, and increases the number of vascular smooth muscle cells. Uridine 5'-O-thiodiphosphate can be used in the research of cardiovascular diseases such as atherosclerosis[1][2].
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Uridine 5'-O-thiodiphosphate | Uridine 5'-O-thiodiphosphate (UDP-β-S) is a P2Y6 receptor agonist with an EC50 of 25 nM. Uridine 5'-O-thiodiphosphate resists degradation by extracellular nucleotidases and stimulates the accumulation of inositol phosphates. Uridine 5'-O-thiodiphosphate stimulates contractile responses in endothelium-denuded rat mesenteric arteries. As a mitogen, Uridine 5'-O-thiodiphosphate stimulates DNA synthesis, [3H] thymidine incorporation, protein synthesis, [3H]leucine incorporation, and increases the number of vascular smooth muscle cells. Uridine 5'-O-thiodiphosphate can be used in the research of cardiovascular diseases such as atherosclerosis. | |||||||||||||||||||||
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References
- [1]. Malmsjö, et al. Characterization of contractile P2 receptors in human coronary arteries by use of the stable pyrimidines uridine 5′-O-thiodiphosphate and uridine 5′-O-3-thiotriphosphate. Journal of Pharmacology and Experimental Therapeutics 293.3 (2000): 755-760. [Content Brief]
- [2]. Hou M, et al. UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors. Am J Physiol Heart Circ Physiol. 2002;282(2):H784-H792. [Content Brief]
