221244-14-0
221244-14-0
Chemical Structure
1-NM-PP1
Synonym(s): PP1 Analog II
- CAS No.: 221244-14-0
- Formula:C20H21N5
- Molecular Weight:331.41
IUPAC Name: 1-(tert-butyl)-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
InChIKey: GDQXJQSQYMMKRA-UHFFFAOYSA-N
SMILES: CC(N1N=C(CC2=CC=CC3=C2C=CC=C3)C4=C(N)N=CN=C41)(C)C
Biological Activity: 1-NM-PP1, a cell-permeable PP1 analog, is a potent Src family kinases inhibitor with IC50s of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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1-NM-PP1 | 98.93% | 1-NM-PP1, a cell-permeable PP1 analog, is a potent Src family kinases inhibitor with IC50s of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively. | ||||||||||||||||||||
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References
- [1]. Bishop A C, et al. Generation of Monospecific Nanomolar Tyrosine Kinase Inhibitors via a Chemical Genetic Approach. Journal of the American Chemical Society, 1999, 121(4):627-631.
- [2]. Bishop AC, et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21;407(6802):395-401. [Content Brief]
