221246-34-0
Chemical Structure
17-trifluoromethylphenyl trinor Prostaglandin F2α
Synonym(s): 17-Trifluoromethylphenyl trinor PGF2α
- CAS No.: 221246-34-0
- Formula:C24H31F3O5
- Molecular Weight:456.50
IUPAC Name: (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-(3-(trifluoromethyl)phenyl)pent-1-en-1-yl)cyclopentyl)hept-5-enoic acid
InChIKey: CMLNDCUXASGBMQ-NQUQXYBYSA-N
SMILES: O[C@@H]1[C@@H]([C@H]([C@@H](C1)O)/C=C/[C@H](CCC2=CC(C(F)(F)F)=CC=C2)O)C/C=C\CCCC(O)=O
Biological Activity: A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic, with a potency equal to or greater than fluprostenol and cloprostenol.
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17-trifluoromethylphenyl trinor Prostaglandin F2α | A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic, with a potency equal to or greater than fluprostenol and cloprostenol. | |||||||||||||||||||||
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