221289-42-5
Chemical Structure
Sampsonione D
- CAS No.: 221289-42-5
- Formula:C38H48O4
- Molecular Weight:568.79
IUPAC Name: (2S,3aS,5R,7S,9R,10aS)-7-benzoyl-5-((E)-3,7-dimethylocta-2,6-dien-1-yl)-1,1,8,8-tetramethyl-2-(prop-1-en-2-yl)octahydro-4H-3a,7:5,9-dimethanocyclopenta[9]annulene-4,6,12(5H)-trione
InChIKey: PHMQDWPJSVBSGB-SWHZHMKXSA-N
SMILES: O=C1[C@@]23[C@@](C(C)([C@@H](C3)C(C)=C)C)([H])C[C@@]4([H])C(C)([C@@]1(C([C@@](C2=O)(C4)C/C=C(C)/CC/C=C(C)\C)=O)C(C5=CC=CC=C5)=O)C
Biological Activity: Sampsonione D is a Hypercohone. Sampsonione D is isolated from the aerial parts of Hypericum cohaerens. Sampsonione D inhibits Alpha-glucosidase, with an IC50 of 116.0 μM against yeast Alpha-glucosidase. Sampsonione D is inactive against Acetylcholinesterase. Sampsonione D exhibits no anticancer activity against non-small cell lung cancer, leukemia, breast cancer, or colorectal adenocarcinoma[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Sampsonione D | Sampsonione D is a Hypercohone. Sampsonione D is isolated from the aerial parts of Hypericum cohaerens. Sampsonione D inhibits Alpha-glucosidase, with an IC50 of 116.0 μM against yeast Alpha-glucosidase. Sampsonione D is inactive against Acetylcholinesterase. Sampsonione D exhibits no anticancer activity against non-small cell lung cancer, leukemia, breast cancer, or colorectal adenocarcinoma. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Nguyen NH, et al. Bio-guided isolation of alpha-glucosidase inhibitory compounds from Vietnamese fruits: and studies. RSC advances. 2023 Nov 30;13(50):35408-35421.
- [2]. Li Y, et al. Polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii Hance and their anti-inflammatory activity. Fitoterapia. 2023 Sep;169:105610. [Content Brief]
- [3]. Lin YL, et al. Polyprenylated phloroglucinol derivatives from Hypericum sampsonii. Helvetica chimica acta. 2003 Jun;86(6):2156-63. [Content Brief]
- [4]. Sriyatep T, et al. Cowabenzophenones A and B, two new tetracyclo [7.3. 3.33, 11.03, 7] tetradecane-2, 12, 14-trione derivatives, from ripe fruits of Garcinia cowa. Fitoterapia. 2014 Jan 1;92:285-9.
- [5]. Liu X, et al. Hypercohones A–C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens. Nat Prod Bioprospect. 2013 Sep 6;3(5):233–7.
