221332-74-7
Chemical Structure
CP-288886
- CAS No.: 221332-74-7
- Formula:C30H28ClF3N2O6S
- Molecular Weight:637.07
IUPAC Name: N-(3-(((3S,4R)-6-((7-chloroquinolin-2-yl)methoxy)-4-hydroxy-2,2-dimethylchroman-3-yl)methyl)-4-methoxyphenyl)-1,1,1-trifluoromethanesulfonamide
InChIKey: JKFSIVODIHADRI-CUBQBAPOSA-N
SMILES: O[C@H]1C2=CC(OCC3=NC4=CC(Cl)=CC=C4C=C3)=CC=C2OC(C)(C)[C@H]1CC5=C(C=CC(NS(C(F)(F)F)(=O)=O)=C5)OC
Biological Activity: CP-288886 is a cysLT1 receptor antagonist with a Ki value of 0.004 μM. CP-288886 exhibits comparable activity to Zafirlukast (HY-17492) and Pranlukast (HY-B0290). CP-288886 inhibits calcium mobilization with an IC50 of 0.0005 μM in human U937 cells. CP-288886 has high oral bioavailability. CP-288886 possesses anti-asthmatic activity in a guinea pig asthma model and can be used for the research of diseases such as asthma[1].
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CP-288886 | CP-288886 is a cysLT1 receptor antagonist with a Ki value of 0.004 μM. CP-288886 exhibits comparable activity to Zafirlukast (HY-17492) and Pranlukast (HY-B0290). CP-288886 inhibits calcium mobilization with an IC50 of 0.0005 μM in human U937 cells. CP-288886 has high oral bioavailability. CP-288886 possesses anti-asthmatic activity in a guinea pig asthma model and can be used for the research of diseases such as asthma. | |||||||||||||||||||||
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