2216703-12-5
Chemical Structure
(R,R)-PCSK9 degrader 1
- CAS No.: 2216703-12-5
- Formula:C53H69FN8O13S
- Molecular Weight:1077.22
IUPAC Name: 4'-(((R)-6-(((R,Z)-6,11-bis((tert-butoxycarbonyl)amino)-2,2-dimethyl-4,12-dioxo-3,16-dioxa-5,7,13-triazaoctadec-5-en-18-yl)oxy)-1-methyl-1-(2-oxo-2-(thiazol-2-ylamino)ethyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)-2'-fluoro-[1,1'-biphenyl]-4-carboxylic acid
InChIKey: BOAJXEFAPWTSFX-ROXLDNMXSA-N
SMILES: OC(C(C=C1)=CC=C1C(C(F)=C2)=CC=C2OC(C(OCCOCCNC([C@H](NC(OC(C)(C)C)=O)CCCN/C(NC(OC(C)(C)C)=O)=N/C(OC(C)(C)C)=O)=O)=C3)=CC4=C3CCN[C@]4(C)CC(NC5=NC=CS5)=O)=O
Biological Activity: (R,R)-PCSK9 degrader 1 is an isomer of PCSK9 degrader 1 (HY-130245). (R,R)-PCSK9 degrader 1 is a HyT-like PCSK9 degrader (IC50 of 655.4 nM) , and its PCSK9-binding site does not interfere with the binding of PCSK9 to LDL receptor. (R,R)-PCSK9 degrader 1 can be used in the research of atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, and related cardiovascular and cardiometabolic diseases[1].
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(R,R)-PCSK9 degrader 1 | (R,R)-PCSK9 degrader 1 is an isomer of PCSK9 degrader 1 (HY-130245). (R,R)-PCSK9 degrader 1 is a HyT-like PCSK9 degrader (IC50 of 655.4 nM) , and its PCSK9-binding site does not interfere with the binding of PCSK9 to LDL receptor. (R,R)-PCSK9 degrader 1 can be used in the research of atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, and related cardiovascular and cardiometabolic diseases. | |||||||||||||||||||||
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