221914-85-8
Chemical Structure
BMS-229724
- CAS No.: 221914-85-8
- Formula:C27H25Cl2F3O5S
- Molecular Weight:589.45
IUPAC Name: 4-(4-(2-((2-(bis(4-chlorophenyl)methoxy)ethyl)sulfonyl)ethoxy)phenyl)-1,1,1-trifluorobutan-2-one
InChIKey: IKQYQTPQMAIVQR-UHFFFAOYSA-N
SMILES: O=C(CCC1=CC=C(OCCS(=O)(CCOC(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)=O)C=C1)C(F)(F)F
Biological Activity: BMS-229724 is an orally active and tight-binding cytosolic phospholipase A2 (cPLA2) inhibitor with an IC50 of 2.8 μM. BMS-229724 can inhibit the production of arachidonic acid and eicosanoids in U937 cells, neutrophils, platelets, and other cells. BMS-229724 has anti-inflammatory activity and can be used in the research of diseases such as skin inflammation[1][2].
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BMS-229724 | BMS-229724 is an orally active and tight-binding cytosolic phospholipase A2 (cPLA2) inhibitor with an IC50 of 2.8 μM. BMS-229724 can inhibit the production of arachidonic acid and eicosanoids in U937 cells, neutrophils, platelets, and other cells. BMS-229724 has anti-inflammatory activity and can be used in the research of diseases such as skin inflammation. | |||||||||||||||||||||
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References
- [1]. Magrioti V, et al. Synthetic inhibitors of group IVA and group VIA phospholipase A2[J]. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistryrrent Medicinal Chemistry-Anti-Inflammatory and Anti-Allergy Agents), 2006, 5(2): 189-203.
- [2]. Burke JR, et al. BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. J Pharmacol Exp Ther. 2001 Jul;298(1):376-85. [Content Brief]
