222159-75-3
Chemical Structure
5-Carboxy-2′,7′-dichlorosulfonefluorescein
Synonym(s): CDCSF
- CAS No.: 222159-75-3
- Formula:C20H10Cl2O8S
- Molecular Weight:481.26
InChIKey: BWRRRHXLZLEVBW-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2C(S(=O)(OC23C4=CC(Cl)=C(C=C4OC5=CC(O)=C(C=C53)Cl)O)=O)=C1)O
Biological Activity: 5-Carboxy-2′,7′-dichlorosulfonefluorescein (CDCSF) is a fluorescein derivative-based fluorescent probe. 5-Carboxy-2′,7′-dichlorosulfonefluorescein serves as a fluorescent substrate for the organic anion transporting polypeptide OATP2B1, and is specifically recognized and transported into cells by OATP2B1 under acidic pH conditions, making it suitable for in vitro high-throughput screening of drug-drug interactions (DDI) and food-drug interactions (FDI) (Ex/Em = 485/535 nm)[1][2].
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5-Carboxy-2′,7′-dichlorosulfonefluorescein | 5-Carboxy-2′,7′-dichlorosulfonefluorescein (CDCSF) is a fluorescein derivative-based fluorescent probe. 5-Carboxy-2′,7′-dichlorosulfonefluorescein serves as a fluorescent substrate for the organic anion transporting polypeptide OATP2B1, and is specifically recognized and transported into cells by OATP2B1 under acidic pH conditions, making it suitable for in vitro high-throughput screening of drug-drug interactions (DDI) and food-drug interactions (FDI) (Ex/Em = 485/535 nm). | |||||||||||||||||||||
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References
- [1]. Kawasaki T, et al. Investigation of Fluorescent Substrates and Substrate-Dependent Interactions of a Drug Transporter Organic Anion Transporting Polypeptide 2B1 (OATP2B1). Pharm Res. 2020 Jun 1;37(6):115.
- [2]. Sugiyama K, et al. The Use of Carboxyfluorescein Reveals the Transport Function of MCT6/SLC16A5 Associated with CD147 as a Chloride-Sensitive Organic Anion Transporter in Mammalian Cells. Journal of pharmaceutical sciences. 2024 Apr;113(4):1113-1120.
