2222114-64-7
2222114-64-7
Chemical Structure
Thalidomide-piperazine-Boc
- CAS No.: 2222114-64-7
- Formula:C22H26N4O6
- Molecular Weight:442.47
IUPAC Name: tert-butyl 4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazine-1-carboxylate
InChIKey: PMKVKOLFYHLKAP-UHFFFAOYSA-N
SMILES: O=C(N1CCN(C2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)CC1)OC(C)(C)C
Biological Activity: Thalidomide-piperazine-Boc is an intermediate that can be used in the synthesis of B-cell lymphoma 6 protein (BCL6) PROTAC[1].
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Thalidomide-piperazine-Boc | 98.82% | Thalidomide-piperazine-Boc is an intermediate that can be used in the synthesis of B-cell lymphoma 6 protein (BCL6) PROTAC. | ||||||||||||||||||||
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Thalidomide-PIP-(R)C-pyrrolidine-boc | Thalidomide-PIP-(R)C-pyrrolidine-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-PIP-(R)C-pyrrolidine-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules. | |||||||||||||||||||||
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E3 Ligase Ligand-linker Conjugate 28 | E3 Ligase Ligand-linker Conjugate 28 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 28 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules. | |||||||||||||||||||||
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E3 ligase Ligand-Linker Conjugate 34 | E3 ligase Ligand-Linker Conjugate 34 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 34 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules. | |||||||||||||||||||||
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E3 ligase Ligand-Linker Conjugate 39 | E3 ligase Ligand-Linker Conjugate 39 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 39 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules. | |||||||||||||||||||||
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E3 Ligase Ligand-linker Conjugate 54 | E3 Ligase Ligand-linker Conjugate 54 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 54 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules. | |||||||||||||||||||||
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E3 Ligase Ligand-linker Conjugate 58 | E3 Ligase Ligand-linker Conjugate 58 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 58 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules. | |||||||||||||||||||||
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Thalidomide-N-methylpiperazine | Thalidomide-N-methylpiperazine is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-N-methylpiperazine can be used to synthesize PROTAC MLKL Degrader-2 (HY-169072) to exhibit antinecroptotic activity on human cell lines and effectively degrade MLKL in the HT-29 xenograft mouse model. | |||||||||||||||||||||
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(3S)Lenalidomide-5-Pip-Boc | (3S) Lenalidomide-5-Pip-Boc is an E3 ligase ligand-linker conjugate that is applicable to research related to PROTAC synthesis. (3S) Lenalidomide-5-Pip-Boc serves as the E3 ligase ligand-linker conjugate for PROTAC ERα Degrader-10 (HY-170336) and PROTAC ER Degrader-14 (HY-170340). | |||||||||||||||||||||
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Thalidomide-piperazine-tert-butyl formate | Thalidomide-piperazine-tert-butyl formate is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC. | |||||||||||||||||||||
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Thalidomide-(1-(3R-pyrrolidinylmethyl)piperazine)-Boc | Thalidomide-(1-(3R-pyrrolidinylmethyl)piperazine)-Boc is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC. | |||||||||||||||||||||
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