2222354-57-4
2222354-57-4
Chemical Structure
HG-12-6
- CAS No.: 2222354-57-4
- Formula:C29H27F3N6O2S
- Molecular Weight:580.62
IUPAC Name: 3-(2-(cyclopropanecarboxamido)thiazolo[5,4-b]pyridin-5-yl)-N-(4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl)benzamide
InChIKey: BBTDRPBKISKELY-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(CN2CCNCC2)C(C(F)(F)F)=C1)C3=CC=CC(C4=CC=C5C(SC(NC(C6CC6)=O)=N5)=N4)=C3
Biological Activity: HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphosphorylated inactive IRAK4 with an IC50 of 165 nM. HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
HG-12-6 | HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphosphorylated inactive IRAK4 with an IC50 of 165 nM. HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
