2223036-84-6
Chemical Structure
DZ-1-DHA
- CAS No.: 2223036-84-6
- Formula:C55H71ClN2O9S
- Molecular Weight:971.68
InChIKey: IQZIWPVDMGEMRT-MEAYZMHJSA-N
SMILES: C[C@@H]1[C@@]2([H])[C@]34[C@@](O[C@@H]1OC(CCCCCN5C6=CC=CC=C6C(C)(/C5=C/C=C7C(Cl)=C(CCC/7)/C=C/C8=[N+](C9=CC=CC=C9C8(C)C)CCCCS(=O)([O-])=O)C)=O)([H])O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C
Biological Activity: DZ-1-DHA is a conjugate of DHA (HY-B2167) and DZ-1 dye. DZ-1-DHA mediates selective cellular uptake via binding to overexpressed OATP1A2. DZ-1-DHA induces the cleavage of Caspase-3, Caspase-8, Caspase-9 and PARP-1. DZ-1-DHA induces Apoptosis and Ferroptosis. DZ-1-DHA induces ROS production through a Fenton-like mechanism, causes mitochondrial membrane depolarization, and triggers lipid peroxidation. DZ-1-DHA can be used in studies related to colorectal cancer liver metastasis[1].
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DZ-1-DHA | DZ-1-DHA is a conjugate of DHA (HY-B2167) and DZ-1 dye. DZ-1-DHA mediates selective cellular uptake via binding to overexpressed OATP1A2. DZ-1-DHA induces the cleavage of Caspase-3, Caspase-8, Caspase-9 and PARP-1. DZ-1-DHA induces Apoptosis and Ferroptosis. DZ-1-DHA induces ROS production through a Fenton-like mechanism, causes mitochondrial membrane depolarization, and triggers lipid peroxidation. DZ-1-DHA can be used in studies related to colorectal cancer liver metastasis. | |||||||||||||||||||||
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