2225889-49-4
2225889-49-4
Chemical Structure
MtTMPK-IN-4
- CAS No.: 2225889-49-4
- Formula:C23H25N3O3
- Molecular Weight:391.46
IUPAC Name: 5-methyl-1-(1-(3-phenoxybenzyl)piperidin-4-yl)pyrimidine-2,4(1H,3H)-dione
InChIKey: BIVAOTFPNQVBDM-UHFFFAOYSA-N
SMILES: CC1=CN(C(NC1=O)=O)C2CCN(CC2)CC3=CC(OC4=CC=CC=C4)=CC=C3
Biological Activity: MtTMPK-IN-4 (compound 2), a para-piperidine, is a potent mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 of 6.1 μM. MtTMPK-IN-4 is a potent tyrosinase inhibitor. MtTMPK-IN-4 is a potent antibacterial agent[1][2].
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MtTMPK-IN-4 | MtTMPK-IN-4 (compound 2), a para-piperidine, is a potent mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 of 6.1 μM. MtTMPK-IN-4 is a potent tyrosinase inhibitor. MtTMPK-IN-4 is a potent antibacterial agent. | |||||||||||||||||||||
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References
- [1]. Lijun Song, et al. Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors. J Med Chem. 2018 Apr 12;61(7):2753-2775. [Content Brief]
- [2]. Jin Li, et al. Recent advances in the design and discovery of synthetic tyrosinase inhibitors. Eur J Med Chem. 2021 Nov 15;224:113744. [Content Brief]
