2226735-54-0
2226735-54-0
Chemical Structure
RIP1 kinase inhibitor 8
- CAS No.: 2226735-54-0
- Formula:C18H19F2N5O2
- Molecular Weight:375.37
InChIKey: XNZJMXBRWHMCOG-INIZCTEOSA-N
SMILES: O=C(C1CCN(C2=NN=C(O2)C)CC1)N3[C@H](C4=CC(F)=CC(F)=C4)CC=N3
Biological Activity: RIP1 kinase inhibitor 8 (Compound 77) is a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor with an IC50 of 20 nM. RIP1 kinase inhibitor 8 prevents necrotic cell death. RIP1 kinase inhibitor 8 shows a favorable pharmacokinetic profile in multiple species[1].
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RIP1 kinase inhibitor 8 | RIP1 kinase inhibitor 8 (Compound 77) is a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor with an IC50 of 20 nM. RIP1 kinase inhibitor 8 prevents necrotic cell death. RIP1 kinase inhibitor 8 shows a favorable pharmacokinetic profile in multiple species. | |||||||||||||||||||||
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