222961-65-1
Chemical Structure
(R)-Thionisoxetine hydrochloride
Synonym(s): LY-368975 hydrochloride
- CAS No.: 222961-65-1
- Formula:C17H22ClNOS
- Molecular Weight:323.88
IUPAC Name: (R)-N-methyl-3-(2-(methylthio)phenoxy)-3-phenylpropan-1-amine hydrochloride
InChIKey: HFMCAKLVRSTANX-XFULWGLBSA-N
SMILES: CSC1=CC=CC=C1O[C@@H](C2=CC=CC=C2)CCNC.Cl
Biological Activity: (R)-Thionisoxetine hydrochloride (LY-368975 hydrochloride) is a potent and selective central and peripheral norepinephrine (NE) uptake inhibitor. (R)-Thionisoxetine hydrochloride prevents 6-hydroxydopamine-induced hypothalamic NE depletion with an ED50 of 0.21 mg/kg. (R)-Thionisoxetine hydrochloride can be used in the study of a variety of diseases, including depression and urinary incontinence[1].
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(R)-Thionisoxetine hydrochloride | (R)-Thionisoxetine hydrochloride (LY-368975 hydrochloride) is a potent and selective central and peripheral norepinephrine (NE) uptake inhibitor. (R)-Thionisoxetine hydrochloride prevents 6-hydroxydopamine-induced hypothalamic NE depletion with an ED50 of 0.21 mg/kg. (R)-Thionisoxetine hydrochloride can be used in the study of a variety of diseases, including depression and urinary incontinence. | |||||||||||||||||||||
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