2230406-52-5
2230406-52-5
Chemical Structure
BCL6-IN-10
- CAS No.: 2230406-52-5
- Formula:C22H23ClF2N6O3
- Molecular Weight:492.91
InChIKey: ZNBLXQLZJFXPAJ-UHFFFAOYSA-N
SMILES: CNC(COC1=CC2=CC(NC3=NC(N4CCC(F)(CC4)F)=NC=C3Cl)=CC=C2N(C1=O)C)=O
Biological Activity: BCL6-IN-10 is a molecular glue inhibitor targeting the BCL6 BTB domain with an IC50 of 4 nM. BCL6-IN-10 blocks the interaction between BCL6 and transcriptional co-repressors, and induces partial degradation of BCL6 via the ubiquitin-proteasome pathway, thereby de-repressing BCL6 target genes and inhibiting cancer cell proliferation. BCL6-IN-10 can be used in the research of diffuse large B-cell lymphoma[1].
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BCL6-IN-10 | BCL6-IN-10 is a molecular glue inhibitor targeting the BCL6 BTB domain with an IC50 of 4 nM. BCL6-IN-10 blocks the interaction between BCL6 and transcriptional co-repressors, and induces partial degradation of BCL6 via the ubiquitin-proteasome pathway, thereby de-repressing BCL6 target genes and inhibiting cancer cell proliferation. BCL6-IN-10 can be used in the research of diffuse large B-cell lymphoma. | |||||||||||||||||||||
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