2230821-68-6
Chemical Structure
SJF-8240
- CAS No.: 2230821-68-6
- Formula:C58H65F2N7O11S
- Molecular Weight:1106.24
IUPAC Name: N-(3-fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
InChIKey: SCUZPTNDZHEHLB-ZWUDBOSPSA-N
SMILES: FC1=CC=C(C=C1)NC(C2(C(NC3=CC(F)=C(C=C3)OC4=CC=NC5=C4C=C(C(OCCCOCCCOCCC(N[C@H](C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=C5)OC)=O)CC2)=O
Biological Activity: SJF-8240 is a selective p38α and c-Met PROTAC degrader. SJF-8240 promotes the ubiquitination and selective degradation of p38α and c-Met. SJF-8240 is applicable to breast cancer-related research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SJF-8240 | 99.33% | SJF-8240 is a selective p38α and c-Met PROTAC degrader. SJF-8240 promotes the ubiquitination and selective degradation of p38α and c-Met. SJF-8240 is applicable to breast cancer-related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019;10(1):131. Published 2019 Jan 10. [Content Brief]
- [2]. Yang L, et al. Advantages of PROTACs in achieving selective degradation of homologous protein families[J]. Beilstein Journal of Organic Chemistry, 2026, 22(1): 628-661.
- [3]. Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3. [Content Brief]
