2231259-57-5
Chemical Structure
IACS-9439-Cl
- CAS No.: 2231259-57-5
- Formula:C23H26ClN7O3S
- Molecular Weight:516.02
IUPAC Name: (1S,2S)-2-((7-chloro-4-methoxy-6-((2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)methoxy)benzo[d]thiazol-2-yl)amino)cyclohexan-1-ol
InChIKey: JYFJGEOXSQLPMB-HOTGVXAUSA-N
SMILES: O(C)C1=C2C(SC(N[C@@H]3[C@@H](O)CCCC3)=N2)=C(Cl)C(OCC4=NC(NC5=CN(C)N=C5)=NC=C4)=C1
Biological Activity: IACS-9439-Cl is a derivative of IACS-9439. IACS-9439 is an orally active and selective colony-stimulating factor 1 receptor (CSF1R) inhibitor with a Kd of 1 nM. IACS-9439-Cl reduces the population of tumor-associated macrophages. IACS-9439-Cl promotes the polarization of macrophages toward the M1 anti-tumor phenotype and decreases the M2 pro-tumor phenotype, thereby exerting a tumor growth inhibitory effect. IACS-9439-Cl can be used in cancer-related research[1].
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IACS-9439-Cl | IACS-9439-Cl is a derivative of IACS-9439. IACS-9439 is an orally active and selective colony-stimulating factor 1 receptor (CSF1R) inhibitor with a Kd of 1 nM. IACS-9439-Cl reduces the population of tumor-associated macrophages. IACS-9439-Cl promotes the polarization of macrophages toward the M1 anti-tumor phenotype and decreases the M2 pro-tumor phenotype, thereby exerting a tumor growth inhibitory effect. IACS-9439-Cl can be used in cancer-related research. | |||||||||||||||||||||
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