2232228-60-1
2232228-60-1
Chemical Structure
EMT inhibitor-2
- CAS No.: 2232228-60-1
- Formula:C24H26N2O8
- Molecular Weight:470.47
IUPAC Name: 4-(2-((2-(3,4-dimethoxyphenyl)-5-hydroxy-6-methoxy-4-oxo-4H-chromen-7-yl)oxy)ethyl)piperazin-2-one
InChIKey: QOLZDEMWVAPPHO-UHFFFAOYSA-N
SMILES: COC1=C(O)C2=C(OC(C3=CC=C(OC)C(OC)=C3)=CC2=O)C=C1OCCN(C4)CCNC4=O
Biological Activity: EMT inhibitor-2 (Compound 1) inhibits epithelial-mesenchymal transition (EMT) induced by substances such as IL-1β and TGF-β released from the immunocytes. EMT inhibitor-2 inhibits CYP3A4 testosteron and CYP2C9 with IC50s of 49.72 and 5.54 μM, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EMT inhibitor-2 | 98.83% | EMT inhibitor-2 (Compound 1) inhibits epithelial-mesenchymal transition (EMT) induced by substances such as IL-1β and TGF-β released from the immunocytes. EMT inhibitor-2 inhibits CYP3A4 testosteron and CYP2C9 with IC50s of 49.72 and 5.54 μM, respectively. | ||||||||||||||||||||
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Recoflavone (Standard) | ≥98% | Recoflavone (Standard) is the analytical standard of Recoflavone (HY-106449). This product is intended for research and analytical applications. Recoflavone (DA-6034 (free acid)), a synthetic derivative of the flavonoid Eupatilin (HY-N0783), is orally active. Recoflavone can inhibit the NF-κB pathway and induce [Ca(2+)]i increase in epithelial cells. Recoflavone exhibits activities such as anti-inflammation, anti-tumor effects, protection of gastric and intestinal mucosa, and promotion of secretion in the ocular surface and salivary glands. Recoflavone can be used for the research of diseases such as dry eye, gastric injury, and intestinal injury. | ||||||||||||||||||||
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Cirsilineol | 98.0% | Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice. | ||||||||||||||||||||
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Sinensetin (Standard) | 98.05% | Sinensetin (Standard) is the analytical standard of Sinensetin. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Eupatilin | 99.23% | Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities. | ||||||||||||||||||||
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Umuhengerin | Umuhengerin is a methoxylated flavone. Umuhengerin can be isolated from Cardiospermum corindum L. | |||||||||||||||||||||
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3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone | 3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone (compound 7) is a flavonoid compound that can be used in research on natural product chemistry and the screening of potential activities of flavonoid compounds. 3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone can be extracted from the dried leaves of Murraya paniculata (a plant of the Murraya genus in the Rutaceae family). | |||||||||||||||||||||
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5,4'-Dihydroxy-6,7,3',5'-tetramethoxyflavone | 99.58% | 5,4'-Dihydroxy-6,7,3',5'-tetramethoxyflavone (Compound 3) is a flavonoid compound that can be isolated from the leaves of *Lantana montevidensis*. 5,4'-Dihydroxy-6,7,3',5'-tetramethoxyflavone possesses potential antioxidant, anti-inflammatory and anti-tumor activities, and can be used in the research of inflammation and cancer. | ||||||||||||||||||||
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Eupatorin (Standard) | ≥98% | Eupatorin (Standard) is the analytical standard of Eupatorin. This product is intended for research and analytical applications. Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage. | ||||||||||||||||||||
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5-Desmethylsinensetin | 99.06% | 5-desmethylsinensetin, isolated from Artemisia princeps , possesses antiprotozoal activity. 5-desmethylsinensetin shows IC50 values of 0.4 μg/mL on T. cruzi epimastigotes and 75.1 μg/mL on trypomastigotes, respectively. | ||||||||||||||||||||
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Eupatorin-5-methyl ether | Eupatorin-5-methyl ether (TMF) can be isolated from Orthosiphon stamineus. Eupatorin-5-methyl ether is a kind of flavonoid compound. Eupatorin-5-methyl ether inhibits NO production (IC |
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